The treatment with DGNS-GW in fibrotic mice increased the expression of the gelatinases MMP-2 and MMP-9 but did not affect the hepatic expression of the associated TIMPs (TIMP-1 and TIMP-2) (Figure 5c), suggesting that the selective activation of PPARγ in hepatic macrophages with DGNS-GW impairs liver fibrosis and modulates macrophage fate towards a pro-resolutive phenotype via the induction of the expression of these extracellular matrix metalloproteinases. This evidence concerns the gene MMP9 and Hepatic fibrosis.