Since macrophages modulate hepatic fibrosis regression through the secretion of matrix metalloproteinases (MMPs) [10,14] but activated HSCs produce tissue inhibitor metalloproteinases (TIMPs) suppressing MMPs activity in late stages of liver fibrosis [2], we wondered whether the selective activation of PPARγ in hepatic macrophages could modulate the liver expression of MMPs and TIMPs. This evidence concerns the gene PPARG and Hepatic fibrosis.