Ding et al. investigated whether the COX-2 inhibitor Celecoxib and the 5-LOX inhibitor MK886 had any synergistic effect on the inhibition of PC cell proliferation because there was evidence that the combination of COX-2 and 5-LOX inhibitors had additive antitumor effect in colon cancer. The gene discussed is ALOX5; the disease is colonic neoplasm.