Further clinical trials are needed to better understand faricimab efficacy and safety in both treatment naïve-patients with DME and w-AMD and in those patients already treated with anti-VEGF agents, which were underrepresented in pivotal, phase III clinical trials (RHINE and YOSEMITE for DME and TENAYA and LUCERNE for w-AMD). This evidence concerns the gene VEGFA and age-related macular degeneration.