CDKN1A and melanoma: To better understand the molecular mechanisms responsible for apoptotic events mediated by solid lipid nanoparticles in COLO-38 melanoma cells, we evaluated the ability of SLNs to modulate the expression of p53, an onco-suppressor protein that plays a key role in apoptotic events, as well as the corresponding p21WAF1/Cip1 target gene.