The COLO-38 melanoma cell line was treated with SLN (5 μL/mL) for 24 h, and our results showed an increase in the cleaved forms, in both treatments, of a well-known substrate of effector caspases, namely ADP RIBOSIUM PO-LYMPHYRASE (PARP) (Figure 4). This evidence concerns the gene PARP1 and melanoma.