LCN2 and hypertensive disorder: Here, we found that daily administration of 10 mg/Kg/day Tac (Tac-10) for 10 days was associated with high blood pressure, an increase in plasma creatinine, and renal damage, represented by the induction in IL-6 and NGAL, two mediators linked to the proinflammatory status [45,46,47,48].