GPX4 and amyotrophic lateral sclerosis: ALS is also characterized by iron accumulation (iron accumulation was detected in the spinal cord of SOD1G37R transgenic mice) [79], lipid peroxidation [levels of 4-hydroxy-2-nonenal (4-HNE) in the serum and cerebrospinal fluid were significantly elevated in sporadic ALS patients] [80], and decreased GPX4 levels (ablation of GPX4 in neurons of a model of ALS resulted in rapid paralysis and severe muscle atrophy) [81].