Similarly, depletion of GSH and GPX4 (GPX4 is associated with neuromelanin production in the SN and dystrophic axons in the PD brain) [74], lipid peroxidation [75,76], system Xc- deregulation [77], and iron accumulation (iron is correlated with an increased risk of α-syn fibers’ formation) [78] have been reported in distinct in vitro and in vivo models of PD. Here, GPX4 is linked to Parkinson disease.