MLXIPL and type 1 diabetes mellitus: In addition, in Akita and OVE26 mice, two genetic models of type 1 diabetes, increased renal triglycerides were correlated with an increased expression of sterol regulatory element-binding protein (SREBP)-1c and carbohydrate response element-binding protein (ChREBP), which, taken together, contributed to an increased fatty acid synthesis [11].