In line with the notion that accumulation of tissue lipids may be a potential source for oxidative stress, a recent study showed that transgenic mice overexpressing nuclear (active) SREBP-1c under control of the phosphoenolpyruvate carboxykinase (PEPCK) promoter (PEPCK-TgSREBP-1c) exhibited renal abnormalities resembling DKD [121]. The gene discussed is PCK2; the disease is diabetic kidney disease.