Thus, photothermolysis, based on near-infrared light-absorbing copper sulfide nanoparticles and 15-ns laser pulses, combined with the immune checkpoint inhibitor anti-PD-1 antibody (αPD-1) increases tumor infiltration via the antigen-presenting cells and CD8-positive T lymphocytes in the B16-OVA mouse model [207]. The gene discussed is CD8A; the disease is neoplasm.