FAP and familial pancreatic carcinoma: In pancreatic cancer, proteolytic enzymes such as the fibroblast-activation protein (FAP), cathepsin proteases, matrix metalloproteinases (MMPs), tumor-associated trypsinogen (TAT), and uroinase-type plasminogen activator (uPA) are usually produced by the tumor cells, its dense stroma, its inflammatory cells, and its activated fibroblasts [84].