IGF1 and neuropathy: Takemura et al. showed that IGF-1 promotes acute resolution of hyperalgesia [31], Contreras et al. suggested IGF-1 prevents vincristine-induced neuropathy [32], Morgado et al. found that IGF-1 prevented behavioral signs of PDN and reversed neuronal hyperactivity [33], and Bitar et al. showed IGF-1 elevates nociceptive threshold and its antinociceptive effects are mediated by tyrosine kinase inhibitors [34].