Moreover, results from Western blot analysis confirmed that the treatment of SKOV-3 with RES combined with cisplatin caused ovarian cancer cell apoptosis via a caspase-dependent pathway observed by a decrease in the full-length caspase-9, caspase 3, and PARP and an increased in their cleaved forms, indicating the activation of caspase proteolytic activity. The gene discussed is CASP3; the disease is ovarian cancer.