AKT1 and ovarian carcinoma: More recently, the combination of curcumin and RES significantly sensitized the epithelial ovarian cancer A2780 (cisplatin-sensitive cell line) and A2780-cis (cisplatin-resistant cell line) to cisplatin, thereby inhibiting ovarian cancer cell chemoresistance via inhibiting the PI3K/AKT/mTOR pathway [57].