STING1 and neoplasm: Moreover, considering that cGAS-STING-IFNβ signaling is associated with innate immunity and secondary acquired immunity and that its chronic and persistent activation may result in a tumor immunosuppressive microenvironment, further studies could focus on the effects of S-72 on immune cells, such as myeloid-derived suppressor cells and cytotoxic T lymphocytes, using mice with normal immune systems [18,56].