In regard to human-derived data, LPS-stimulated CD14+ macrophages alone mixed with the T cell subpopulation CD4+ CD45+ RO, isolated from the peripheral blood of IBD patients, showed a decrease in pro-inflammatory cytokine production as well as a significantly induced apoptosis of the mentioned cell populations after 24 h of treatment with 5 μg/mL EGCG [39]. The gene discussed is CD4; the disease is inflammatory bowel disease.