The reasons for the irrelevance are non-MIRI models (diabetic cardiomyopathy, myocardial fibrosis, cardiotoxicity, and myocardial infarction, high glucose-induced injury in cardiomyocytes, inorganic mercury-induced cardiac injury), other signaling pathways such as PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway, NFkB signaling, IGF-1R/Nrf2 signaling, and the PI3k/Akt signaling pathway were not measured. This evidence concerns the gene NFKB1 and Myocardial fibrosis.