The effects on the renal haemodynamics and excretion of ADA, an enzyme that reduces the level of adenosine (endogenous agonist of A1, A2, and A3 receptors) and the effects of A2aR selective antagonist, were determined in anaesthetised NG and DM rats with short- or long-lasting hyperglycaemia. Here, ADA is linked to Hyperglycemia.