The univariate Cox regression analysis revealed that RYK expression status (high vs. low, hazards ratio (HR) = 0.46; 95% confidence interval (CI), 0.23–0.94, p = 0.033) (Supplementary Figure S6b) was a significant risk factor for OS in the IDH mutant TCGA glioma patient subgroup. This evidence concerns the gene RYK and glioma.