Our subsequent univariate analysis of IDH wildtype grade 4 GBM cases revealed that both low (vs. high) and medium (vs. high) RYK expression levels were significantly associated with improved OS (HR = 0.46; 95% CI, 0.25–0.87; p = 0.016, and HR = 0.52; 95% CI, 0.28–0.97; p < 0.04, respectively) (Supplementary Figure S9a,b). This evidence concerns the gene RYK and glioblastoma.