Secretagogues mostly generate hypoglycemia, DPP-4 inhibitors principally generate gastrointestinal discomfort, incretin mimetics generate hypoglycemia and nausea, GLP-1 inhibitors cause intestinal discomfort, vomiting, and in some cases diarrhea, with respect to a-glucosidase inhibitors, the principal side effect is flatulence generation and abdominal distension, and finally, the SGLT inhibitors can cause urinary tract infections, genital infections and a possible risk of bladder cancer [35,36]. This evidence concerns the gene GCG and Hypoglycemia.