Several oncogenic signaling pathways, including the EGFR pathway that is deregulated in GBM, contribute to GBM progression by converging on the important STAT3 molecular hub that controls critical biological functions, including cell proliferation, differentiation, survival, angiogenesis, and the tumor immune response [10,26,27,28,29,30,31,32,33,34]. Here, EGFR is linked to glioblastoma.