STAT3 and glioblastoma: Utilizing STAT3 knockout (STAT3-KO) GBM cells and STAT3-KO cells restored with wild-type STAT3 or mutants deficient in Y705ph or S727ph showed that deregulated STAT3 activation in GBM cells suppressed autophagy as determined by the phosphorylation of AMPKα and Unc-51-like kinase 1 (ULK-1).