Deregulated PDGFR signaling is a frequent oncogenic driver in a subset of GBM, and one consequence of oncogenic PDGFR signaling is increased early growth response 1 (EGR1)-dependent transcription of the METTL3 RNA methyltransferase that methylates RNA to generate N6-methyladenosine (m6A) [105]. The gene discussed is PDGFRB; the disease is glioblastoma.