The PRRs most relevant for virus infections include Toll-like receptors (TLRs), the retinoic acid-inducible gene I-like receptors (RLRs), the nucleotide oligomerization domain-like receptors (NLRs, also called NACHT, LRR, and PYD domain proteins) and cytosolic DNA sensors such as DNA-dependent activator of IFN-regulatory factors (DAI), IFN-inducible factor 16 (IFI16), Ku70, stimulator of IFN genes (STING), and cyclic GMP-AMP (cGAMP) synthase (cGAS) [29,30]. Here, ZBP1 is linked to viral infectious disease.