IFNA1 and infection: Although the genetic basis of this mouse strain-dependent susceptibility is not yet fully understood, a significant but limited number of cellular genes, such as those involved in dsRNA- and interferon (IFN)-mediated innate immune responses, have been shown to affect mouse susceptibility to infection with one or more flaviviruses, such as WNV, ZIKV, DENV, and YFV [222].