The main areas of unsolved issues regard the number and categories of eliminated foods, the optimal duration of the elimination diet, the development of new IgE-mediated food allergies, the adoption of less invasive modalities of endoscopic evaluation, such as the Cytosponge, for both the diagnosis of EoE and food reintroduction, and diet long-term efficacy. Here, IGHE is linked to eosinophilic esophagitis.