The ratio of HDL/non-HDL (Figure 4e) was only increased by ANP, which means that ANP mainly reduced non-HDL and has a less reducing effect on HDL, although the serum levels of WD-induced high T-Cho (Figure 4b) and non-HDL (Figure 4d) were significantly reduced by all of ANE, ANP, and ARE. Here, NPPA is linked to Wilson disease.