PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Previous genome-wide association studies (GWAS) and candidate gene studies have identified genetic loci associated with NAFLD incidence, such as patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulator (GCKR), and lysophospholipase-like 1 (LYPLAL1) [8,9,10,11].