To calculate the PHS of the NAFLD-associated FGF21 pathway, 226 SNPs at the loci of FGF21 and its receptors were initially obtained from the FGF21, FGFR1, FGFR2, FGFR3, and KLB loci. This evidence concerns the gene FGFR3 and metabolic dysfunction-associated steatotic liver disease.