FGF21 and metabolic dysfunction-associated steatotic liver disease: To investigate these associations, we (1) developed a polygenic hazard score (PHS) via the discovery and combination of multiple-loci SNPs related to the FGF21 pathway based on a longitudinal cohort of the Korean population, (2) analyzed the risk of NAFLD incidence based on the PHS, and (3) explored the possible modifying effect of protein intake.