A recent systematic review and meta-analysis of twenty-one randomized controlled trials (RCTs) in patients with T2DM reported that, compared to controls, dietary fiber at a median daily dose of 10 g/day for a mean intervention duration of 8 weeks significantly reduced glycated hemoglobin A1c (HbA1c), fasting glucose and insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [28]. This evidence concerns the gene INS and Insulin resistance.