Moreover, using high fat diet induced NAFLD mice models it has been shown that supplementation with indole derivatives (indole, IPA and IAA) protected against fatty liver and downregulated specific lipogenic genes, such as Acetyl CoA carboxylase (ACC), and fatty acid synthase (FAS) [28,41,83,85]. The gene discussed is FASN; the disease is metabolic dysfunction-associated steatotic liver disease.