One study investigated the links between oral cancer and VDR gene polymorphisms (CYP27B1 and CYP24A1), which regulate the anabolism and catabolism of vitamin D, and found that the CYP24A1 gene polymorphism might influence oral cancer and that the VDR FokI polymorphism was associated with worse survival and could be an independent prognostic marker [42]. This evidence concerns the gene CYP24A1 and lip and oral cavity carcinoma.