With respect to liver health, TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin), the most toxic dioxin, has been shown to alter blood and hepatic lipid levels, disrupt bile synthesis, impair the microbiome, and strongly contribute to NAFLD development and progression through the activation of aryl hydrocarbon receptor (AhR) [103,104,105,106,107]. This evidence concerns the gene AHR and metabolic dysfunction-associated steatotic liver disease.