The consumption of drinking water containing BPA during gestation impairs the PI3K/Akt/mTOR (PI3K/Akt/mammalian target of rapamycin) and TLR4/NF-κB pathways in the liver of offspring rats, resulting in the upregulation of lipogenic genes, activation of the inflammatory response, dysregulation of autophagy and development of NAFLD [265]. The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatotic liver disease.