ESR1 and metabolic dysfunction-associated steatohepatitis: Notably, such a female-specific and ERα-dependent feature is associated with the ability to preserve the hepatic homeostasis of amino acids (AA), especially of branched-chain amino acids (BCAA) [29], in agreement with studies reporting an impaired BCAA metabolism [30,31] and sex-dimorphic changes in BCAA levels in patients with NAFLD/NASH [32].