In rodents, PFAAs-induced liver steatosis and toxicity have been mainly attributed to PPARα, which activation leads to increased expression of genes involved in FAO, lipogenesis (Srebf1, sterol regulatory element-binding transcription factor 1; Fasn, fatty acid synthase), and lipid uptake (Cd36) [77]. The gene discussed is CD36; the disease is Hepatic steatosis.