In human liver organoids, 1 μm polystyrene MPs microbeads have been found to disrupt lipid metabolism by increasing the expression of HNF4A, alter ATP production, promote ROS generation, oxidative stress by inducing CYP2E1 (cytochrome P450 family 2 subfamily E member 1), inflammation, lipotoxicity, and hepatotoxicity, thus providing evidence for the implication of these particles in human NAFLD [170]. The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatotic liver disease.