In addition, DOX can be directly co-delivered with p53, other chemotherapeutic agents (e.g., methotrexate and rapamycin) [169], or MDR reversal agents (e.g., efflux pump inhibitors or redox cell state modulators) via nanocarriers to directly or indirectly synergistically induce cancer cell apoptosis by increasing p53 [167,170,171]. This evidence concerns the gene TP53 and cancer.