Hou et al. reported that exosomes secreted from ccRCC cells promote angiogenesis through miR-27a, which targets secreted frizzled-related protein 1 (SFRP1) mRNA [78], and increased expression of SFRP1 induces angiogenesis [79,80]. The gene discussed is SFRP1; the disease is nonpapillary renal cell carcinoma.