Ten of them (FN1, TLN1, ITGB3, HSPA8, TUBA4A, CD9, CD63, HSPG2, ITGB1, and GNAI2) that were measured in at least five samples were denoted as components of an EV proteomic signature associated with CRC. The gene discussed is ITGB3; the disease is colorectal carcinoma.