Cytokine stimulation in HLH patients reduces CD47 expression [25], interleukin 4 (IL-4), IL-7, and IL-13 influence CD47 expression on Sezary cells [26], and the expression level of CD47 in cancer cells is regulated by miR-133a, MYC oncogene, and the ERK signaling pathway [27,28,29]. This evidence concerns the gene CD47 and hemophagocytic syndrome.