HIF1A and neoplasm: They may prevent the development of tumour angiogenesis modulating expression and activity of some of factors and cellular pathways associated with this process, such as vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 alpha (HIF-1α), protein kinase B (Akt) pathway, and extracellular signal-regulated kinase (ERK) pathway.