Mannans are able to inhibit the inflammatory response in macrophages and appear to play an important role in the development, propagation, control, and resolution of IBD; mannans from cabernet franc, cabernet sauvignon, and sauvignon blanc wines were found to reduce the production of pro-inflammatory factors (IL-1β, TNF-α, NO) in LPS-induced RAW264.7 cells [116]. This evidence concerns the gene TNF and inflammatory bowel disease.