The significance of the chemistry and bioactivity of these aralkyl phytocannabinoids 1–7, isolated from the EtOH extracts of the stem bark, led to the examination of their binding affinities for CB1, CB2 and opioid (κ, δ and μ) receptors, using radioligand assays, together with their cytotoxic activities and modulation towards cancer-related signaling pathways. This evidence concerns the gene CNR2 and cancer.