In addition to flavonols, the flavanone hesperetin sensitized cisplatin (DDP)-resistant human lung cancer cells (A549/DDP) to cisplatin in vivo and in vitro, mechanistically through the decreased expression of P-gp and the increased intracellular accumulation of the P-gp substrate, rhodamine 123 [81]. The gene discussed is PGP; the disease is lung carcinoma.