Even though the exact mechanism of the occurrence of NAFLD is still unclear, oxidative stress; enhanced TG and TC levels; hepatic fat accumulation; the activation of nuclear factor kappa-B/NLR family and the pyrin domain-containing protein 3 (NF-κB/NLRP3) inflammasome; and the eventual formation of liver fibrosis are all factors that interact and induce synergistic effects [42]. The gene discussed is NFKB1; the disease is Hepatic fibrosis.