For example, El-Seweidy et al. conducted a study that revealed that 10-dehydrogingerdione possesses a proprotein convertase subtilisin/kexin type 9 (PCSK9) lowering effect, which may be responsible for its cardiovascular protective effect against dyslipidemia through a mechanism that modulates lipid levels [88]. This evidence concerns the gene PCSK9 and metabolic syndrome.