GCK and type 2 diabetes mellitus: Other studies reported that quercetin treats T2D by reducing hyperglycemia, enzyme levels, liver glucose content, high blood pressure, serum cholesterol levels, and hyperlipidemia, as well as by encouraging weight loss [230,232], lowering blood sugar levels [233,234,235], improving glucose tolerance [233,236] and hepatic glucokinase activity [236], and enhancing the subsequent release of insulin and pancreatic cell regeneration [237,238].