A growing body of evidence from in vivo and in vitro studies points to a substantial role for dietetic polyphenols in treating type II diabetes (T2D) through insulin-dependent tactics, such as protecting pancreatic islet cells, reducing cell apoptosis, promoting islet cell proliferation, attenuating oxidative stress, activating insulin signaling, and stimulating insulin secretion [33]. The gene discussed is INS; the disease is type 2 diabetes mellitus.