INS and Hypercholesterolemia: On the other hand, a different study found curcumin (90 mg/kg BW) with insulin (1 U/day vs. 4 U/day) in STZ-induced rats decreased hyperglycemia, hypercholesterolemia, and biochemical markers of kidney and liver damage while increasing the activity of glutathione peroxidase and superoxide dismutase (hepatic antioxidants) [194].