Similarly, Jain reported that curcumin diet supplements (50 or 100 mg/kg BW) decrease hyperglycemia and inflammatory processes in STZ-induced diabetic rats by preventing McP-1, HbA1c, TNf-α, IL-6, and lipid peroxidation and suppressing the NF-kB signaling pathway; protecting against inflammation [202]; and restoring normal antioxidant enzymes levels, including catalase, glutathione peroxidase, and SOD [203]. This evidence concerns the gene SOD1 and Hyperglycemia.