strong induction of apoptosis in human melanoma cells as a result of imbalance between pro and anti-apoptotic proteins from the Bcl-2 familyno apoptotic changes in melanocytescaspase and mitochondrial pathway-dependent apoptosis (caused by lower mitochondrial membrane potential and greater activation of Bak and Bax)lowering the level of Mcl-1 in melanoma cells resulting in stronger apoptosis of cancer cells. This evidence concerns the gene BAX and cancer.