Expression levels of NADPH oxidases (NOXs), NADPH oxidase activity, oxidative stress through the levels of glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) in brain tissues were determinedEGb-761 shows high antioxidant activitythere are possibilities of using this substance of natural origin in medicine (treating diseases of the nervous system). This evidence concerns the gene FMO5 and nervous system disorder.