BCL2 and neoplasm: Anti-proliferative activity against the HeLa, HepG2, NCI-H460, Daudi, K562, SKOV3, MIAPaca-2, MCF-7 tumor cell lines was examinedbilobetin and isogingetin had the strongest anti-proliferative effects against different tumor cell linesHeLa cells were the most sensitive to bilobetin and isogingetin (induction of cell apoptosis)inhibition of the tumor cell cycle in the G2/M phaseactivating the protein Bax and executive caspase-3bilobetin inhibited the production of Bcl-2 (a protein with an anti-apoptotic effect)