effect on metabolic disorders in mice with obesity induced by a high-fat dietactivation of hPXR transactivitydecrease in body weight and serum triglyceride (TG) levelsreduction of fatty liver (improvement of lipid accumulation)increase in mRNA expression of target PXR genes in the liver. This evidence concerns the gene NR1I2 and obesity due to melanocortin 4 receptor deficiency.