ATL II inhibits cancer cell proliferation and causes apoptosis primarily through regulating the PI3K/Akt, JAK2/STAT3, Ras/ERK, JNK/ERK-Nrf2-ARE, and LncRNA XIST/miR-30a-5p/ROR1 signaling pathways to treat colon, gastric, lung, melanoma, breast, and prostate cancers. Here, JAK2 is linked to cancer.