CASP3 and malignant colon neoplasm: By promoting Bax, Caspase-9, and Caspase-3, inhibiting Bcl-2 protein expression, and regulating the Bax/Bcl-2 apoptotic signaling pathway in human colon cancer cells, ATL III inhibits cell proliferation and induces apoptosis in HCT-116 cells, producing anti-colon cancer effects [69].