ATL I inhibits cancer cell proliferation and induces apoptosis primarily by regulating the PI3K/Akt, JAK2/STAT3, TLR4/MyD88/NF-κB, Notch, and ERK/GSK3β signaling pathways to treat colon, gastric, lung, melanoma, ovarian, breast, bladder, leukemia, prostate, and cervical cancers. This evidence concerns the gene STAT3 and cancer.