CEA and neuron-specific enolase (NSE), two lung cancer markers, have been simultaneously determined using SERS tags prepared by surface modifications of flower-like gold nanoparticles with Raman molecules and specific antibodies, while magnetic nanoparticles modified with mixed antibodies are used as capturing substrates for separation of immunocomplexes from the reaction mixture [134]. Here, CEACAM5 is linked to lung cancer.