For rapidly progressive ADPKD, a broad spectrum of urinary proteins was identified, including the maximal upregulation of the Notch pathway, MAST-4 proteins, and EGFR-kinase, as part of accelerated cell proliferation and the sorting of the nexin vesicular proteins, plakoglobin, desmoplakin, fibronectin, vitronectin, radixin, ezrin, tenascin, and uromodulin (reflecting cyst expansion, cell–cell-adhesion disruption, and cytoskeletal abnormalities). This evidence concerns the gene UMOD and autosomal dominant polycystic kidney disease.