LEM domain-containing protein 3 (LEMD3) gene mutations have been described in several familial cases of melorheostosis; there was no direct correlation with this pathology, but they were directly associated with other hereditary dysplasias such as osteopoikilosis (OPK), a melorheostosis-associated disease presenting with a hyperostosis phenomenon similar to melorheostosis [4]. Here, LEMD3 is linked to hyperostosis.