Testosterone deficiency can lead to dental symptoms including osteoporosis, decreased alveolar bone support, periodontal diseases, xerostomia and subsequent caries, and methods to avoid false readings include testing early morning total testosterone, sexual hormone binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) [29,48]. This evidence concerns the gene PLOD1 and periodontal disorder.