Furthermore, in the transmembrane 6 superfamily member 2 (TM6SF2) gene, which controls cholesterol synthesis in hepatocytes and the secretion of lipoproteins, the rs58542926 variant (p.E167K) has been associated with altered mechanisms that drive an increase in liver fat content, fibrosis, and HCC [20]. Here, TM6SF2 is linked to hepatocellular carcinoma.