Therefore, its early recognition is crucial and should start with a clinical evaluation by considering risk factors for the rapid development of fibrosis, such as insulin resistance and T2DM, obesity, sarcopenia, the presence of NASH in non-obese patients, or elevated alanine aminotransferase (ALT) levels above the normal upper limits [59], which should be confirmed with diagnostic tests [60]. This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.