LEP and obesity due to melanocortin 4 receptor deficiency: Another study revealed that no statistically significant association of Lep with SBP or DBP was obtained among the subjects having a higher BP, and it was understood that Lep may balance and elevate the arterial tone for increasing DBP only within the normal BP limit [21], and it was concluded that Lep might serve as a physiological mediator or at least a potential marker for increasing the DBP in obesity conditions [21].