The analysis for the entire CNSL cohort shows similar results to those found for the PCNSL group with ECOG PS (p < 0.001 and p < 0.001), albumin levels (p = 0.007 and p = 0.017), <3 cycles of chemotherapy (p < 0.001 and p = 0.026) and ASCT (p = 0.001 and p = 0.020) representing statistically significant risk factors for OS in both the univariate and multivariate regression. The gene discussed is ALB; the disease is primary central nervous system lymphoma.