Age at diagnosis (OR = 0.929, IC 95% 0.868–0.994, p = 0.03) and stimulated Tg levels (measured at the time of RAI) (OR = 1.015, IC 95% 1.001–1.029, p = 0.04) were confirmed to be significant risk factors for one-year tumour recurrence, independently of several confounders, including sex, BMI, histopathological features, metastatic lymph nodes at diagnosis and radioiodine activity. The gene discussed is TG; the disease is neoplasm.