This tumor acid environment causes several clinical effects such as: decreasing drug uptake in tumor cells due to the altered protonation state, selecting highly aggressive and drug-resistant phenotypes with stem cell characteristics, enhancing invasion and metastatic processes, inducing VEGF angiogenesis, and decreasing immune infiltration of the tumors, leading to the development of a more malignant phenotype [24]. Here, VEGFA is linked to neoplasm.