ALDH2 and fatty liver disease: To this end, the following hypotheses were evaluated: (i) the polymorphism of the ADH1B and ALDH2 genes results in different serum metabolites, which influence the development of liver steatosis, inflammation, and fibrosis in patients with NAFLD; (ii) BMI may be associated with ADH1B/ALDH2 in patients of Asian ethnicity with NAFLD.