Recently the results of a multi-omics study (COVID-19 Multi-Omic Blood Atlas, COMBAT Consortium) highlighted an increased frequency of activated CD4+ and CD8+ T cells in all COVID-19 patient groups, with a reduction in CD4+ TH1, CCL5+CD8+ T central memory, CD45RA+CD8+ T effector memory, and NK cells in hospitalized cases. This evidence concerns the gene CD8A and COVID-19.