However, a potential role for IFN-γ in MIS-C pathogenesis has been suggested in a multicenter cohort reported by Hoste et al., with significantly elevated levels of CXCL9 (chemokine C-X-C motif ligand 9) and CXCL10 in both MIS-C and COVID-19 patients [86], in line with similar observations in MIS-C by Caldarale et al. (in Italy) [68], Carter et al. (in the United Kingdom) [87], Esteve-Sole et al. (in Spain) [88], and Diorio et al. (in the United States) [89]. This evidence concerns the gene CXCL9 and COVID-19.